• We conclude that we have established xeno free fibroblast

  2018-10-22

  

  We conclude, that we have established xeno-free fibroblast feeder cell lines using HS-containing culture medium and, in accordance with published data agree, that HS is a feasible substitute for FBS (Richards et al., 2003; Kibschull et al., 2011; Ellerstrom et al., 2006; Meng et al., 2008; Unger et

• An interesting remaining question is

  2018-10-22

  

  An interesting remaining question is whether hemogenic endothelial cells are already committed to producing blood or whether any endothelial cell is capable of doing so depending on the influence of a singular environment. It is of interest to note that hemogenic endothelial cells found in different

• ABT-263 Given the proven ability of

  2018-10-22

  

  Given the proven ability of transcription factors to artificially induce pluripotency in somatic ABT-263 (Takahashi and Yamanaka, 2006), the high expression of these factors in the germline (Kurimoto et al., 2008) raises the question of how PGCs are constrained from becoming pluripotent and thereby

• Hence we propose a model

  2018-10-22

  

  Hence, we propose a model in which transient HES5 activity in early mesoderm instructs the timing of cardiac fate specification while repressing the first wave of hematopoiesis. Thus in the absence of this signal, commitment to EryP is favored by default. Moreover, after a pulse of Hes5 instructing

• Main Text It is remarkable that only years

  2018-10-22

  

  Main Text It is remarkable that only 20 years after the first report of the growth of human embryonic stem Manumycin A in vitro and just 10 years after discovering that somatic cells can be reprogrammed to pluripotency as induced pluripotent stem cells (iPSCs), the results of the first clinical tr

• The following are the supplementary data

  2018-10-20

  

  The following are the supplementary data related to this article. Acknowledgments This work was supported by Marie-Curie IEF FellowshipPIEF-GA-2009-254644 (J.F.) and the Netherlands Institute for Regenerative Medicine (NIRM) (E.W., M. vd. B. and T.N.). Introduction Human ES (hES) cells are p

• Like pro NGF Fahnestock et al

  2018-10-20

  

  Like pro-NGF (Fahnestock et al., 2001; Peng et al., 2004) pro-BNDF is the precursor protein of BDNF, which is abundant in the hippocampus (Barker, 2009; Bekinschtein et al., 2014; Lessmann and Brigadski, 2009; West et al., 2014). Pro-BDNF undergoes cleavage by a family of mammalian processing enzyme

• Neurospheres are also a good source of neural progenitors fo

  2018-10-20

  

  Neurospheres are also a good source of neural progenitors for neural transplantation due to their easy delivery and ability to migrate (Matigian et al., 2010; Englund et al., 2002; Flax et al., 1998; Betarbet et al., 1996). However, clumping has been a challenge for neurodifferentiation both in vivo

• The alternative corneal epithelial stem cell CESC hypothesis

  2018-10-20

  

  The alternative corneal epithelial stem cell (CESC) hypothesis (Majo et al., 2008) accepts that LESCs exist but proposes that these are only used to repair wounds and that, during normal homeostasis, the corneal epithelium is maintained by stem cells, which are present throughout the corneal epithel

• Our experiments suggest that Runx may

  2018-10-20

  

  Our experiments suggest that Runx1 may be a useful target to manipulate in order to direct the endogenous NSPC proliferative response toward maximal neurogenesis following traumatic melanotropin injury. Runx1 over-expression has been demonstrated to facilitate neuronal differentiation and long-range

• Recent publications provide inconsistent results whether the

  2018-10-20

  

  Recent publications provide inconsistent results whether the overexpression of KLF4 is consistently accompanied with a more favorable outcome in all gastrointestinal cancer types. In HCC the gaba b receptor pattern of KLF4 is significantly increased compared to corresponding adjacent non-tumor samp

• br Author contributions br Conflict of interests

  2018-10-20

  

  Author contributions Conflict of interests Acknowledgments We thank Dr. Wenying Liu for her help with the initial setup of the electrospinning and Mr. Xiyu Li for his assistance with SEM. We also thank Emory Children\'s Pediatric Research Center Flow Cytometry Core and Animal Physiology Cor

• br Methods br Results br Discussion

  2018-10-20

  

  Methods Results Discussion Our method for osteoprogenitor cell culture is similar to protocols for mice (Meirelles and Nardi, 2003; Soleimani and Nadri, 2009; Nardi and Camassola, 2011; Abdelmagid et al., 2014; Fig. 1). Marrow and cortex-derived cell populations of bats and mice shared simi

• Erastin Supplier Indeed both hAT MSC and

  2018-10-20

  

  Indeed, both hAT-MSC and hiPS-MSC baACL implants, when validated in a swine ACL excision model, resulted in proper ACL tissue formation. In the osseous zones, both in the tibia and the femur, the fibres of the biomaterial were surrounded by newly formed tissue that was encapsulated within mature bon

• miR expression was strikingly down regulated in

  2018-10-20

  

  miR-410 expression was strikingly down-regulated in the adult SVZ following Noggin over-expression in our inducible transgenic mice (Morell et al., 2015). Noggin was initially characterized by its ability to rescue the phenotype of UV light-dorsalized embryos (Smith and Harland, 1992; Lamb et al., 1

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