• Human adult tissue derived MSCs have

  2018-10-24

  

  Human adult-tissue-derived MSCs have shown therapeutic utility in experimental autoimmune encephalitis (EAE) models of MS (Bai et al., 2009; Gordon et al., 2008, 2010; Peron et al., 2012; Zhang et al., 2005) and in clinical trials for MS patients (Connick et al., 2012; Karussis et al., 2010; Mohyedd

• By continuously observing hundreds of individual HSCs

  2018-10-24

  

  By continuously observing hundreds of individual HSCs and their progeny during differentiation, we can exclude a change in cell-cycle length in HSPCs upon GADD45G expression, which was unexpected, because studies on solid tissue GSK-3 Inhibitor IX reported a G2/M cell-cycle arrest mediated by GADD45

• br Introduction The grafting of

  2018-10-24

  

  Introduction The grafting of cultured keratinocytes to promote regeneration represents one of the oldest clinical examples of stem cell therapy (Green, 2008). The skin constitutes an essential barrier between the living tissues of the body and the external environment, and skin tissues have evolv

• Cisplatin and Vorinostat alone produced exciting results but

  2018-10-24

  

  Cisplatin and Vorinostat alone produced exciting results, but their combination was extremely efficient in disrupting CSCs and non-CSCs. After 5days of combined therapy, CSCs were completely depleted in HACC2A cells, and a 3.9-fold reduction in CSCs occurred in HACC6 sodium channel (Fig. 4A and B).

• The first consistency check we performed was that the normal

  2018-10-24

  

  The first consistency check we performed was that the “normal metabolism” scenario, defined as baseline HDM activity and lack of induction of stemness transcription factors, should lead to cell differentiation. Figure 1B shows that, after an initial transient regime, the system settles down to a ste

• Etonogestrel To elucidate whether the expression

  2018-10-24

  

  To elucidate whether the expression pattern of Zscan4 has any correlation with ESC proliferation, we monitored Zscan4 activity at single cell level. Also to see whether the rejuvenation factor Zscan4 correlates with the fluctuating wave of ESC pluripotency (Figure S1), we monitored Zscan4 and the pl

• However in these models human hematopoietic

  2018-10-24

  

  However, in these models, human hematopoietic reconstitution is usually B-lymphoid dominant, and engraftment of human myeloid, erythroid, and megakaryocyte lineages is limited (Doulatov et al., 2012; Ito et al., 2012; Rongvaux et al., 2013; Yamauchi et al., 2013). This skewed reconstitution could be

• br Results br Discussion Experimental transdifferentiation

  2018-10-24

  

  Results Discussion Experimental transdifferentiation of transcription factor by ectopic expression of conditional C/EBPα has shed light on the molecular dynamics of the conversion of lymphoid cells into inflammatory macrophages (Bussmann et al., 2009; Di Tullio et al., 2011; Krijger et al., 2

• br Results br Discussion Although hiPSCs have been

  2018-10-24

  

  Results Discussion Although hiPSCs have been directed to differentiate into various organoids/tissues and in vitro differentiation from bovine iPSCs toward a partial mammary phenotype has been reported (Cravero et al., 2015), generation of mammary organoids/cells from hiPSCs has not been estab

• br Experimental Procedures See Supplemental Experimental Pro

  2018-10-24

  

  Experimental Procedures See Supplemental Experimental Procedures for additional details. Author Contributions Acknowledgments Derivation and characterization of H1-ECs and RNA-seq experiments were supported by NIH in collaboration with the Defense Advanced Research Projects Agency and the

• One of the significant challenges in understanding embryonic

  2018-10-24

  

  One of the significant challenges in understanding embryonic HSC development has been the lack of methods to distinguish clonal precursors of HSCs from temporally and phenotypically overlapping progenitors lacking HSC potential, which is necessary to identify the unique properties and lineage potent

• br Comparing the result with we conclude

  2018-10-24

  

  Comparing the result with (2), we conclude that the initial radius of the Universe in the proposed model of the Universe is about 20 times less than the “tunneling” Vilenkin radius. The testing function of the initial state (20), as well as the initial radius of the Universe (24) are approximate

• The electrostatic spectrographs are not yet industrially man

  2018-10-24

  

  The electrostatic spectrographs are not yet industrially manufactured and the devices proposed are rather the experimental models (see Refs. [2, 4–6]). A theory for designing potential structures where the spectrographic mode is implemented has been developed at our Laboratory of Corpuscular Optic

• There was an attempt to explain the physiological meaning of

  2018-10-24

  

  There was an attempt to explain the physiological meaning of the balance between the oligomeric and the monomeric forms of the sigma-1 receptor by the hypothesis that oligomerization of the sigma-1 receptor regulates its ligand-mediated functions [57]. Presumably, the sigma-1 receptor ligands can in

• br Conclusion To summarize we have developed a method for

  2018-10-24

  

  Conclusion To summarize, we have developed a method for determining Young\'s modulus of the sample surface using an AFM with an optical system for detecting the position of the probe organized by the interferometric principle. We have obtained the temperature dependence for the spring constant of

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