• DUBs are involved in cell

  2019-08-26

  

  DUBs are involved in 98 2 kinase regulation and DNA damage pathways and since, in cancer and different stress conditions all the proteins which regulate cell cycle and DNA damage/repair are either up/down regulated (Singh et al., 2013, Singh et al., 2011, Kumar and de Massy, 2010, Gupta et al., 201

• br Introduction Vitis vinifera L

  2019-08-26

  

  Introduction Vitis vinifera L. is one of the most worldwide-grown fruit crop and is mostly used in the wine industry (Bouquet, 2011). Domestication and history changed dramatically the biology of this species and today there are thousands of V. vinifera varieties, being many of them closely relat

• Here we investigate in more

  2019-08-26

  

  Here we investigate in more detail how Dot1 function contributes to the regulation of DNA damage tolerance. We find that Dot1 modulates the response to the alkylating agent MMS through its catalytic activity on H3K79. In fact, progressively reduced levels of H3K79 tri-methylation result in gradually

• Films treated with Diaz ES VWFIIINle but not

  2019-08-26

  

  Films treated with Diaz-ES-VWFIIINle but not exposed to UV light supported only slight platelet deposition, suggesting that passively-bound peptides were removed under shear. However, treatment with Diaz-ES-VWFIIINle and UV restored platelet surface coverage to about 50% of the level on native colla

• The DDR gene located on chromosome region p encodes

  2019-08-26

  

  The DDR1 gene, located on chromosome region 6p21.33, encodes a transmembrane tyrosine kinase receptor involved in melanocyte anchoring through binding to collagen IV (Silva de Castro et al., 2010). So far, only three studies have been conducted on the association between DDR1 polymorphism and the ri

• In order to assess quantitatively the contribution of the un

  2019-08-26

  

  In order to assess quantitatively the contribution of the ung, dug and dut UNC 0646 to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. The method, which w

• In conclusion by investigating the cysteine protease transcr

  2019-08-26

  

  In conclusion, by investigating the cysteine protease transcriptome in soybean nodules, we found a number of cysteine proteases belonging to the C1 and C13 families strongly up-regulated following drought exposure such as C1 cysteine protease Glyma.14G085800 and C13 cysteine proteases Glyma.17G23070

• br Conclusions Cereal seeds like the seeds of all

  2019-08-26

  

  Conclusions Cereal seeds, like the seeds of all plants, are responsible for the development, protection, dispersal, and nutrition of the next generation. Moreover, cereal caryopses have a high nutritional value for humans and animals. The stable and proper growth of cereal seeds is made possible

• br Introduction Analyses of genomic alterations

  2019-08-26

  

  Introduction Analyses of genomic alterations in cancer have identified epidermal growth factor receptor (EGFR) as one of the most potent “oncogenic driver” kinases that is present in many epithelial tumors including endometrial, breast, prostate, skin, esophagus, lung, stomach, colorectal, and re

• br Results On the th day the horizontal Fig

  2019-08-26

  

  Results On the 8th day, the horizontal (Fig. 1) and vertical locomotor activity (Fig. 2) and the dorsal (Fig. 3) and acetylcholine receptors striatal dopamine release (Fig. 4) increased significantly in nicotine-treated rats, compared with the saline-treated rats. Tukey post-hoc test revealed th

• Another important mediator in fear learning is the neuropept

  2019-08-26

  

  Another important mediator in fear learning is the neuropeptide corticotropin-releasing factor (CRF). For example, local repeated administration of CRF into the basolateral amygdala potentiates the acquisition of cue-conditioned fear (Bijlsma et al., 2011) and CRF1 receptor antagonists effectively b

• br Results On the th day the horizontal Fig

  2019-08-26

  

  Results On the 8th day, the horizontal (Fig. 1) and vertical locomotor activity (Fig. 2) and the dorsal (Fig. 3) and Annexin V-Cy5 Apoptosis Kit striatal dopamine release (Fig. 4) increased significantly in nicotine-treated rats, compared with the saline-treated rats. Tukey post-hoc test reveale

• SIS3 kinase br Acknowledgments Denise Fernandes acknowledges

  2019-08-26

  

  Acknowledgments Denise Fernandes acknowledges a postdoc fellowship (SFRH/BPD/34289/2006) from the Portuguese Fundação para a Ciência e Tecnologia (FCT) of the Ministry of Science and Technology of Portugal. This work was supported by the Spanish National Plan for Research (Project Ref. CGL2011-24

• Among the various neurotransmitter systems pointed out to

  2019-08-24

  

  Among the various neurotransmitter systems pointed out to play a role in the mediation of defensive and antinociceptive responses elicited by environmentally aversive stimuli, the neuropeptide corticotropin-releasing factor or hormone (CRF or CRH) has attracted the interest of many researchers inves

• CPH models reported usually as lists of risk factors along

  2019-08-24

  

  CPH models, reported usually as lists of risk factors along with their parameters, are prevalent in medical literature. One such model is the CPH model created for the purpose of predicting the probability of one year survival of patients suffering from Pulmonary Arterial Hypertension [5]. The model

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