• br En gran mayor a las mujeres

  2018-10-25

  

  En gran mayoría, las mujeres académicas de mi generación en las universidades estadounidenses llegamos al profesorado por medio de los programas de acción afirmativa que, impulsados por poderosos movimientos sociales, transformaron las facultades en los años 70. Por puertas que antes no existían,

• Banks generate additional cash for the

  2018-10-25

  

  Banks generate additional cash for the economy by turning deposits into loans. Our study shows that deposits have a positive association with bank liquidity. Bonner et al. (2013) also had similar findings. However, Alger and Alger (1999); Dinger (2009) and Kashyap et al. (2002) found a negative rela

• br Summary and conclusions br Introduction Historically

  2018-10-24

  

  Summary and conclusions Introduction Historically, the foundations of the concept that the heart is a static organ incapable of regeneration were established in the mid-1920s. A significant publication in 1925 claimed that mitotic figures are not detectable in human cardiomyocytes (Karsner et

• More interestingly our data suggest that SRT might suppress

  2018-10-24

  

  More interestingly, our data suggest that SRT3025 might suppress p21 transcription through the down-regulation of Egr1. Egr1 modulates p21 gene expression and also plays important functions in HSPC development and proliferation (Krishnaraju et al., 2001; Min et al., 2008; Ragione et al., 2003). With

• miR a has been extensively studied

  2018-10-24

  

  miR-29a has been extensively studied in different fields. miR-29a has been reported to be associated with cardiac hypertrophy and fibrosis (Roncarati et al., 2014), and functions as a negative regulator of extracellular matrix remodeling (van Rooij et al., 2008). We have previously reported that miR

• Human adult tissue derived MSCs have

  2018-10-24

  

  Human adult-tissue-derived MSCs have shown therapeutic utility in experimental autoimmune encephalitis (EAE) models of MS (Bai et al., 2009; Gordon et al., 2008, 2010; Peron et al., 2012; Zhang et al., 2005) and in clinical trials for MS patients (Connick et al., 2012; Karussis et al., 2010; Mohyedd

• By continuously observing hundreds of individual HSCs

  2018-10-24

  

  By continuously observing hundreds of individual HSCs and their progeny during differentiation, we can exclude a change in cell-cycle length in HSPCs upon GADD45G expression, which was unexpected, because studies on solid tissue GSK-3 Inhibitor IX reported a G2/M cell-cycle arrest mediated by GADD45

• br Introduction The grafting of

  2018-10-24

  

  Introduction The grafting of cultured keratinocytes to promote regeneration represents one of the oldest clinical examples of stem cell therapy (Green, 2008). The skin constitutes an essential barrier between the living tissues of the body and the external environment, and skin tissues have evolv

• Cisplatin and Vorinostat alone produced exciting results but

  2018-10-24

  

  Cisplatin and Vorinostat alone produced exciting results, but their combination was extremely efficient in disrupting CSCs and non-CSCs. After 5days of combined therapy, CSCs were completely depleted in HACC2A cells, and a 3.9-fold reduction in CSCs occurred in HACC6 sodium channel (Fig. 4A and B).

• The first consistency check we performed was that the normal

  2018-10-24

  

  The first consistency check we performed was that the “normal metabolism” scenario, defined as baseline HDM activity and lack of induction of stemness transcription factors, should lead to cell differentiation. Figure 1B shows that, after an initial transient regime, the system settles down to a ste

• Etonogestrel To elucidate whether the expression

  2018-10-24

  

  To elucidate whether the expression pattern of Zscan4 has any correlation with ESC proliferation, we monitored Zscan4 activity at single cell level. Also to see whether the rejuvenation factor Zscan4 correlates with the fluctuating wave of ESC pluripotency (Figure S1), we monitored Zscan4 and the pl

• However in these models human hematopoietic

  2018-10-24

  

  However, in these models, human hematopoietic reconstitution is usually B-lymphoid dominant, and engraftment of human myeloid, erythroid, and megakaryocyte lineages is limited (Doulatov et al., 2012; Ito et al., 2012; Rongvaux et al., 2013; Yamauchi et al., 2013). This skewed reconstitution could be

• br Results br Discussion Experimental transdifferentiation

  2018-10-24

  

  Results Discussion Experimental transdifferentiation of transcription factor by ectopic expression of conditional C/EBPα has shed light on the molecular dynamics of the conversion of lymphoid cells into inflammatory macrophages (Bussmann et al., 2009; Di Tullio et al., 2011; Krijger et al., 2

• br Results br Discussion Although hiPSCs have been

  2018-10-24

  

  Results Discussion Although hiPSCs have been directed to differentiate into various organoids/tissues and in vitro differentiation from bovine iPSCs toward a partial mammary phenotype has been reported (Cravero et al., 2015), generation of mammary organoids/cells from hiPSCs has not been estab

• br Experimental Procedures See Supplemental Experimental Pro

  2018-10-24

  

  Experimental Procedures See Supplemental Experimental Procedures for additional details. Author Contributions Acknowledgments Derivation and characterization of H1-ECs and RNA-seq experiments were supported by NIH in collaboration with the Defense Advanced Research Projects Agency and the

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