• br Methods The Spanish GEM MAS trial lasted from

  2019-05-09

  

  Methods The Spanish GEM05MAS65 trial lasted from March, 2006 to October, 2008 and included 260 patients from 63 Spanish centers. At study entry, every patient was aged 65 years or older and had newly diagnosed, untreated, symptomatic, measurable MM. These patients had received a homogeneous induc

• FDA-approved Drug Library br Conflict of interest br

  2019-05-09

  

  Conflict of interest Introduction Case report A 5-year-old boy was admitted for treatment of atrial flutter after correction of pulmonary atresia with ventricular septal defect. The patient had undergone total correction of cardiac disease at 4 years and 2 months of age after previous bila

• br Conflict of interest br

  2019-05-09

  

  Conflict of interest Case presentation A 64-year-old female presented to the emergency room with persistent dizziness that began early that morning. She had a 30-year history of palpitations and known electrocardiogram (ECG) abnormalities. Her pulse was irregular at 130–270min−1 and blood pres

• br Case report A year old man with

  2019-05-09

  

  Case report A 54-year-old man with a surgically repaired DORV was admitted to our hospital due to palpitations and worsened right ventricular heart failure. He had been diagnosed with DORV and had undergone the Blalock Taussig operation at 7 years of age. He underwent the Rastelli operation at 35

• Although these studies demonstrated the efficacy of

  2019-05-09

  

  Although these studies demonstrated the efficacy of pacemaker treatment for preventing or reducing VVS, all 3 trials were retrospective and uncontrolled [10]. Therefore, RCTs of cardiac pacing in VVS were proposed in the late 1990s. The era of RCTs: is pacemaker efficacy due to a placebo effect?

• br Alternans and arrhythmogenesis in different

  2019-05-09

  

  Alternans and arrhythmogenesis in different clinical conditions APD alternans, whether spatially concordant or discordant, can produce arrhythmias. For example, spatially concordant alternans themselves can produce 2:1 conduction block, thereby initiating re-entry [48]. Nevertheless, discordant a

• Furthermore an observational cross sectional case control st

  2019-05-08

  

  Furthermore, an observational, cross-sectional case-control study used by the authors of 976 children aged 6–10 years, from an area of small towns immersed in the countryside in central Italy, estimated the rate of FAS as between 4 per 1000 and 12 per 1000 people in 2011. These rates cannot in any c

• There are several limitations to the

  2019-05-08

  

  There are several limitations to the procedure described herein. The present GC was developed for engaging the coronary sinus via a right-sided approach. However, this GC was bent dorsally and had the shortest tip and most acute tip angle among the Attain™ family, which facilitated its placement int

• br Material and methods br Results br Discussion

  2019-05-08

  

  Material and methods Results Discussion The present study provides clinical, molecular, and in vitro electro-physiological evidence that a rare SNP (KCNE1-D85N) can act as a genetic modifier in LQTS. In general, SNPs are thought to be non-pathological, but some have been reported to modify

• We herein report a patient

  2019-05-08

  

  We herein report a patient with dMMR and MSI-H metastatic gastric cancer who SAR405 responded favorably and durably to PD-1 blockade. This patient, along with the previous two demonstrated by Le et al, are up-to-date the only 3 MMR gastric cancer patients who responded well to PD-1 blockade. Respon

• In this study we applied a more general approach along

  2019-05-08

  

  In this study, we applied a more general approach along these lines, which has previously been used only in few reports in the literature [8]. Based on a prospective BC database including all newly diagnosed BC cases at a large Swiss breast center over a 20-year period, we aimed to give a comprehens

• Las colaboraciones de Woinoff conforman el ltimo

  2019-05-08

  

  Las colaboraciones de “Woinoff ” conforman el último vértice de la constelación intelectual que, necessary nuestro juicio, pudo haber ayudado en el cambio intelectual de Bilbao. En ellas, el pretendido “atraso” se vuelve reserva moral desde la cual la democracia radical europea puede pensar de maner

• br Introduction Multiple signal transduction

  2019-05-08

  

  Introduction Multiple signal transduction pathways in normal and malignant Solamargine converge on Bcl-2 family proteins, which stand at the crossroads between cell survival and apoptosis. The seminal event in the intrinsic pathway of apoptosis is mitochondrial outer membrane permeabilization (M

• Although the study is of

  2019-05-08

  

  Although the study is of a high quality given the constraints of the case-control design, we question whether it alone provides sufficient evidence for this policy recommendation. Observational studies of ITNs are notoriously fraught with challenges. Even in settings in which randomised trials show

• br Discussion Variant angina was described by Prinzmetal

  2019-05-08

  

  Discussion Variant alkaline phosphatase inhibitors was described by Prinzmetal et al. in 1959 [1]. It can involve serious arrhythmias such as ventricular tachycardia, ventricular fibrillation, and atrioventricular block, and patients are particularly susceptible to sudden cardiac death in such c

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