Recently several studies have suggested that peripheral bloo

2018-10-20

Recently, several studies have suggested that peripheral blood mononuclear purchase SYN-117 (PBMCs) are a promising resource for generating iPSCs because most of these cells do not undergo TCR rearrangement (Loh et al., 2010; Mack et al., 2011; Seki et al., 2010). However, PBMCs are composed of sev

TPCA reversibly binds to IKK and prevents it

2018-10-20

TPCA-1 reversibly binds to IKKβ and prevents it from phosphorylating IκBα for degradation and thereby blocks nuclear translocation of NF-κB (Kondo et al., 2008). Our results demonstrate that TPCA-1 may inhibit the stimulatory action of TNF-α on NF-κB. TPCA-1 partially inhibits secretion of constitut

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2018-07-29