• The mechanism of the system Xc increase may be linked

  2018-11-06

  

  The mechanism of the system Xc− increase may be linked to the hypoxia signaling cascade. Hypoxia increases HIF-1α which leads to an increase in multiple genes. In order to demonstrate the role of HIF-1α signaling in xCT regulation we probed blots from 10% hypoxia treated azidothymidine with HIF-1α

• br Experimental Procedures br Acknowledgments We are gratefu

  2018-11-06

  

  Experimental Procedures Acknowledgments We are grateful to Rosalind Gunby and Monica Autiero for careful reading and critical comments of the manuscript. We thank the Animal House and the Integrated Microscopy Facilities of IGB-Consiglio Nazionale delle Ricerche (CNR) and the Bioinformatic Cor

• br Results and Discussion br Author Contributions br Acknowl

  2018-11-06

  

  Results and Discussion Author Contributions Acknowledgments Introduction Specific control of cellular fate by biological surface modification has garnered recent attention for the ability to create biomimetic microenvironments (Lutolf and Hubbell, 2005). Normally, the body contains stem

• Human PGCs are specified in the embryo between

  2018-11-06

  

  Human PGCs are specified in the embryo between the second and third week of life after fertilization. Similar to mice, human PGCs are first localized outside of the embryo, then they migrate into the embryo during week 3, ultimately entering the genital ridges and indifferent gonads between the four

• The ubiquitin proteasome degradation mechanism is

  2018-11-06

  

  The ubiquitin–proteasome degradation mechanism is associated with most intracellular proteins, including membrane-surface receptors (Gesbert et al., 2005; Martinez-Moczygemba et al., 2007; Rocca et al., 2001; Wauman et al., 2011). Over 60 Fbox proteins have been identified, but only a few, such as β

• There have been reports showing the linkage between kidney

  2018-11-06

  

  There have been reports showing the linkage between kidney dysfunction and lipid metabolization (Cignarelli and Lamacchia, 2007; Hall et al., 2003; Kramer, 2006; Maric-Bilkan, 2013; Wickman and Kramer, 2013). Indeed, we found that BMSCs isolated from PNx mice have higher rates of adipogenesis after

• In the experiments described in this report molecular and ce

  2018-11-06

  

  In the experiments described in this report, molecular and cellular processes downstream of SOX18 were studied in a non-endothelial background. Effects of SOX18 expression on ASCs were manifested in an endothelial-like cell morphology and responsiveness to forces exerted by laminar flow. SOX18 induc

• br Cardiomyocyte cycling increases after myocardial injury b

  2018-11-06

  

  Cardiomyocyte cycling increases after myocardial injury, but does not lead to effective regeneration In adult mice after experimental myocardial infarction, the border zone shows a 10-fold increase of cardiomyocyte EHT 1864 activity. As described above, the α-MHC-MerCreMer mouse in combination w

• br Materials and methods br Results br Discussion

  2018-11-06

  

  Materials and methods Results Discussion Since the report of iNSCs in 2012 (Sheng et al., 2012a,b), several other groups have also published studies on iNSCs, using different starter lipoxygenase and reprogramming factors (Kim et al., 2014; Cheng et al., 2014a; Cheng et al., 2014b; Cheng,

• The goal of this study was to

  2018-11-06

  

  The goal of this study was to identify an additional cell-surface marker that, when combined with CD133, could further distinguish and enrich PCFUs. Cell surface markers that were previously known to enrich non-pancreas progenitor cells, including CD71 (transferrin receptor), were screened. CD71 tra

• The pluripotency of MPSII line was confirmed by alkaline pho

  2018-11-06

  

  The pluripotency of MPSII-4.1 line was confirmed by alkaline phosphatase staining (ALP) and by immunocytochemistry staining (ICC) for endogenous NANOG and -CADHERIN (B) after silencing of the exogenous hOKSM construct. The spontaneous differentiation potential of the iPSC line towards the three ge

• Using bisulfite sequencing and Southern blotting analyses we

  2018-11-06

  

  Using bisulfite sequencing and Southern blotting analyses, we demonstrated previously that the major and minor satellites of pericentromeric heterochromatin are hypomethylated only in germ cell lineages, whereas all somatic purchase KN-93 are hypermethylated, and that this DNA methylation profile i

• Although the mechanisms of in vitro postovulatory aging

  2018-11-05

  

  Although the mechanisms of in vitro postovulatory aging and in vivo reproductive aging differ, there are some remarkable cytological similarities relevant to human reproduction. It has been reported that aging of human and mouse oocytes can result in disorganization of the spindle and defects in chr

• We next assessed how reflective the HDR editing

  2018-11-05

  

  We next assessed how reflective the HDR editing rates calculated via deep-sequencing were of actual editing rates. Hence, the CTS protocol was repeated for all seven variants independently, and approximately 250 clonal populations were then picked and analyzed via Sanger sequencing. We successfully

• br Conclusion Despite its limitations this research addresse

  2018-11-05

  

  Conclusion Despite its limitations, this research addressed several aspects of fall prevention and rehabilitation. First, it leukotriene receptor agonist showed that frailty and falls were closely interrelated; falls may be a reliable indicator of frailty and may be systematically researched by

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