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Materials and Methods br Results br Discussion
2020-03-06
Materials and Methods Results Discussion For several decades, the diagnosis of translocation-associated childhood sarcomas with overlapping morphological characteristics has been facilitated by pathognomonic gene fusion detection through RT-PCR or FISH. However, these assays have several shor
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Nicardipine HCl receptor p and p which are downstream of pAk
2020-03-06
p21 and p16, which are downstream of pAkt and pERK1/2, are tumor suppressors which induce cell senescence and Nicardipine HCl receptor arrest [[56], [57], [58]]. Inhibitors of pAkt or pERK1/2 can activate p21 and p16 and promote cell senescence and cell cycle arrest [11,12,[59], [60], [61]]. It is
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Importantly MPO is not only a marker of cardiovascula http
2020-03-06
Importantly, MPO is not only a marker of cardiovascular disease but also emerges as a critical mediator of vascular inflammatory disease: Liberated MPO binds to the endothelium in a leukocyte-independent manner, is subsequently taken up by the endothelium and transcytoses and accumulates in the sub
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On the other hand the
2020-03-06
On the other hand, the interaction of the Kaempferia parviflora extract with CYP3A was uncompetitive with a low Vmax value. In the in vivo study, the Kaempferia parviflora extract did not interfere with CYP3A activity throughout the entire duration of treatment. This is fortunate as CYP3A isoforms a
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The component E of PDHc PDHc
2020-03-06
The component E1 of PDHc (PDHc-E1) catalyzes the first step of multistep processes, using thiamine diphosphate (ThDP) and Mg2+ as cofactors.15, 16 Especially, this PDHc-E1 catalyzed process is a rate limiting step among multistep processes. Accordingly, the PDHc should be inactive by inhibiting the
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Our previous studies have demonstrated that the DDR discoidi
2020-03-06
Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma
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DDR expression is upregulated in
2020-03-06
DDR1 expression is upregulated in the glomeruli and tubules of injured kidneys [7], [8], [19]; however, what role this receptor plays in kidney resident Scriptaid is unclear. A plausible hypothesis is that DDR1 might contribute to kidney injury by directly exerting a pro-fibrotic action. In favor to
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Some mechanistic experiments performed in the early s
2020-03-06
Some mechanistic experiments performed in the early 2000s by Ongusaha et al. [78], suggest that DDR1 induction protects Hesperadin from apoptosis in a p53-dependent manner, and that impairment of DDR1 expression or function leads to a pronounced increase of DNA damage-induced apoptosis. This eviden
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Autophagy alterations are frequently reported as one of
2020-03-06
Autophagy alterations are frequently reported as one of the pathological mechanisms contributing to neurodegenerative diseases, due to incomplete removal of protein BQ-788 sodium salt in the brain [30,41]. It was over a decade ago when mutations in PARK8 encoding for the LRRK2 protein were describe
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Testosterone is inactivated through hydroxylation
2020-03-06
Testosterone is inactivated through hydroxylation and conjugation pathways [3], [4]. 6β-Hydroxylation is the main pathway among testosterone hydroxylation processes in the liver microsome. Testosterone 6β-hydroxylation is mainly catalyzed by cytochrome P450 3A (CYP3A) [5], [6], which is expressed in
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Besides the enhanced expression of
2020-03-06
Besides the enhanced expression of costimulatory and adhesion proteins, also the expression of the CD83 surface molecule is strongly enhanced during DC maturation (Banchereau and Steinman 1998; Banchereau et al. 2000). In fact, CD83 is a major cell surface marker for fully mature DC, as it can not b
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Our approach relied on measurement of bulk
2020-03-06
Our approach relied on measurement of bulk solute diffusivity in the three tissue types of interest. Our diffusivity values (Table 3) are on the order of 10−6 cm2/s and are comparable to the PG diffusion coefficient in water at infinite dilution, which is about 10−5 cm2/s at room temperature, as wel
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br Funding sources br Introduction Psychiatric comorbidities
2020-03-06
Funding sources Introduction Psychiatric comorbidities affect up to 70% of people with pharmacoresistant epilepsy and significantly impact quality of life [1]. Psychiatric comorbidities in epilepsy have been thought to be due to psychosocial stress. However, recent evidence suggests a more com
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Interest in the PGE EP pathway is increasing given its
2020-03-06
Interest in the PGE2/EP4 pathway is increasing given its diverse capability of regulating central nervous system activity [13]. EP4 has a protective function by reducing cerebral injury and improving functional outcome after stroke [14], and in suppressing hth 7 in 1 receptor inflammation [15]. The
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br Summary and perspectives In recent decades enormous
2020-03-05
Summary and perspectives In recent decades, enormous advances have been achieved in the development of enzyme-activatable imaging probes, enabling the accurate detection of enzyme activity in vivo to better understand the biological function of enzymes in disease processes. Activatable probes are
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