• br Conclusions br Declaration of interest br Acknowledgment

  2020-12-29

  

  Conclusions Declaration of interest Acknowledgment This work was supported by an AIRC (Associazione Italiana Ricerca Cancro-Milan) Grant KFR062-2 to A.G.L, by Ricerca Funds by Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (Grant No. 180/01) and by the ERA-NET “ERare” (Grant GO

• Efavirenz br Substrate characterization of candidate peptide

  2020-12-29

  

  Substrate characterization of candidate peptide reporters in a library Measurement of resistance to intracellular proteases Use of capillary zone electrophoresis for assay readout Selection of lead peptide from small library screen Characterization of final reporter Additional modif

• Although the reasons why viral RNA

  2020-12-29

  

  Although the reasons why viral RNA does not bind to and activate PKR in WNV-infected cells are not known, some of the known characteristics of flavivirus infections provide possible clues. The viral Vitamin D3 sale protein forms dimers that associate with ER membranes and viral RNA (Lindenbach et al

• Our study found a significant association between the degree

  2020-12-29

  

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P D-Mannitol status. However, only a small portion of these previous studies included the evaluation of lobulation, and almost all of them reported no association between EGFR mutation

• Structural homology modelling Intensive Phyre modelling was

  2020-12-29

  

  Structural homology modelling. Intensive Phyre2 modelling [44] was performed using the primary amino TAPI-1 sequence of A1S_0222 as input to generate an atomistic 3D-homology model of A1S_0222. The fit to the SAXS data of the homology model as well as the fit to the data of the E. coli adenine-N6-D

• cAMPS-Rp, triethylammonium salt Introduction Collagen deposi

  2020-12-29

  

  Introduction Collagen deposition is a common feature found in cancerous tissues and fibrotic organs/lesions. It is now well accepted that collagen deposition is not just a consequence of disease, but that it can also trigger a vicious cycle. Both chemical and physical signals elicited from collagen

• Isochlorogenic acid A As the COMT enzyme is primarily

  2020-12-29

  

  As the COMT enzyme is primarily related to prefrontal dopamine degradation (e.g., Yavich et al., 2007), the present study supports the notion that prefrontal dopamine modulates retention of fear extinction rather than within-session extinction (Abraham et al., 2014). Consistent with other studies we

• br Materials and methods br Results br Discussion One

  2020-12-28

  

  Materials and methods Results Discussion One novel finding in our study is that CK2 inhibition preserved axon function and structure in WM against ischemia. Consistent with these findings, oligodendrocytes, astrocytes, myelin, and BI-847325 were found to express CK2α. The robust expression

• br Experimental Procedures br Author Contributions H G

  2020-12-28

  

  Experimental Procedures Author Contributions H.G. and X.-Y.F. conceived and designed the project. H.G., D.V.D., and X.L. performed most of the experiments and analyzed the data. L.X. helped on Mettl8 KO ESC, RIP, and translational study. Y.S. performed FACS analysis. Y.W. helped with cardiomyo

• br Conclusions We can conclude that Arg is

  2020-12-28

  

  Conclusions We can conclude that Arg293 is important but not indispensable for MeGlcA recognition by EcXyn30A since the R293A variant still retains activity and preference for MeGlcA-substituted substrates. The substrate specificity of GH30_8 glucuronoxylanases is most probably determined by an o

• br Guidance of B cell localization

  2020-12-28

  

  Guidance of B cell localization by EBI2 EBI2 expression and B cell disease Although chemoattractant receptors of the GPR family play essential roles in coordinating the migration of lymphocytes for efficient responses against pathogens, their dysregulation can result in the initiation or progr

• Ubiquitination can occur on a single monoubiquitination or s

  2020-12-28

  

  Ubiquitination can occur on a single (monoubiquitination) or several (multiubiquitination) lysine residues, or the same lysine residue can be subjected to several rounds of Ub conjugation (polyubiquitination). Ub bonds within polyUb chains are formed through 1 of 7 lysine residues in Ub, and the typ

• Here we describe preparation of three stable conjugates that

  2020-12-28

  

  Here, we describe preparation of three stable conjugates that are linked by either oxyester, disulfide, or isopeptide bonds (Fig. 10.1). Each of these conjugates depends upon the prior purification of E2 and ubiquitin proteins that have been engineered to favor specific linkages. For the oxyester-

• Subgroup analysis showed that patients with relatively lower

  2020-12-28

  

  Subgroup analysis showed that patients with relatively lower CrCl levels (>50–80 mL/min) were more likely to initiate treatment on a lower dose (17% for all DPP-4 inhibitors; 22% excluding linagliptin). Nevertheless, even in patients with higher CrCl value (>80–120 mL/min and >120 mL/min), at least

• br Introduction Sphingolipids are ubiquitous membrane compon

  2020-12-28

  

  Introduction Sphingolipids are ubiquitous membrane components of all eukaryotic cells belonging to a group of complex lipids. The basic structure of sphingolipids is composed of a sphingoid long chain base (LCB) linked to a fatty hedgehog inhibitor via an amide bond to form a ceramide [1]. In ani

15537 records 691/1036 page Previous Next First page 上5页 691692693694695 下5页 Last page