• Several reports have exploited the

  2021-03-11

  

  Several reports , , , , have exploited the application of HRM for detecting differentially methylated DNA. Even though DNA methylation analysis by HRM cannot determine the methylation status of individual CpGs, it does provide a robust and inexpensive method to differentiate DNA based on the overal

• The Nile tilapia Oreochromis niloticus

  2021-03-11

  

  The Nile tilapia (Oreochromis niloticus) is an important farmed fish with an XX/XY sex-determining system. The availability of the whole genome sequence of tilapia and tissue transcriptomes (Brawand et al., 2014), together with its gonadal transcriptomes at different developmental stages (Tao et al.

• MPI-0479605 Regarding their reported beneficial properties o

  2021-03-11

  

  Regarding their reported beneficial properties on the digestive tract, the aim of this study was to evaluate the effect of water extracts of three Hypericum sps., HP, HA, HU and some of the main phenolic compounds (Ch, R and Q) on DNA protection against oxidative and alkylating DNA damage induced by

• br Conclusion br Acknowledgments br Introduction

  2021-03-10

  

  Conclusion Acknowledgments Introduction Arsenic (As) is one of the most toxic metals derived from the natural environment in soil, air and well water. It has two oxidative states: a trivalent form, arsenite, and a pentavalent form, arsenate. The inorganic As is more toxic than organic As. A

• We hypothesized that the atopic phenotype may be partially i

  2021-03-10

  

  We hypothesized that the atopic phenotype may be partially influenced by an altered binding and/or signalling due to the amino-acid substitution in the receptor protein. The principal aim of this study was to investigate the signalling mechanisms of the variants CysLT1-G300S and CysLT1-I206S induced

• igf-1 receptor Targeting a specific cell type rather than th

  2021-03-10

  

  Targeting a specific cell type, rather than the broad cytotoxicity exhibited by some of the pharmacological agents currently used to treat lupus, may improve efficacy and decrease off target toxicity. Thus, evidence that macrophages and microglia are important to the pathogenesis of LN and NPSLE, re

• All of these experiments in GM matter injury

  2021-03-10

  

  All of these experiments in GM matter injury models have identified an array of signaling mechanisms that are potentially important. First, Kim et al. proposed that CK2 acts as a negative modulator of NADPH oxidase [55]. Then Blanquet et al. [50] found that increased CK2 correlated with inhibition o

• Therapeutic options targeting intrahepatic resistance are ve

  2021-03-10

  

  Therapeutic options targeting intrahepatic resistance are very limited. Theoretically, the NO-cGMP pathway may be influenced at several sites. Yet, most strategies did not reach clinical practice or yielded disappointing results, such as activators of soluble guanylate cyclase [14], NO releasing der

• Finally we have determined for the first time that aromatase

  2021-03-10

  

  Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent Rufinamide receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cultures (Kretz et al., 200

• br Stem cell based therapies In

  2021-03-10

  

  Stem cell–based therapies In the previous years, excessive efforts have been conducted to induce the least aggression and more efficient sources of human cardiomyocytes for different application, particularly for myocardial regeneration. The pluripotent stem cell seems to be an appropriate candid

• RNA seq results also support the similarity between

  2021-03-10

  

  RNA-seq results also support the similarity between ESC- and YS-derived B-1 progenitors. Bmi1 expression, known as an important gene for self-renewal ability in stem cells, was reduced in ESC-derived B cells compared with YS-derived B cells, and Bmi1 overexpression improved the engraftment of ESC-de

• Additional derivatives were synthesised using a modified app

  2021-03-09

  

  Additional derivatives were synthesised using a modified approach (). Commercially available 4-bromo-2-methoxyaniline () was converted into the boronic ester , followed by a Suzuki–Miyaura cross-coupling with chromenone triflate to afford the corresponding arylamine . Acylation of with chloroacetyl

• As part of a program to explore the key

  2021-03-09

  

  As part of a program to explore the key binding interactions between the core of 1 and DGAT-1 a systematic analysis of the aminopyrimidine subunit was initiated. A potential approach to improving passive permeability within this series would be to increase lipophilicity via incorporation of substitu

• br Alcohol and the amygdala br Alcohol and

  2021-03-09

  

  Alcohol and the amygdala Alcohol and the CRF1 system Given the marked effects of alcohol on inhibitory neurotransmission in the amygdala and the regulation of amygdalar GABAergic activity by CRF and activity at the CRF1 receptor, the CRF system is a logical site for the actions of alcohol in t

• The regression also revealed a significant association betwe

  2021-03-09

  

  The regression also revealed a significant association between admission selectivity (SELECT) and exam pass rate (PASS%) (p WAY-100635 maleate salt mg serve as an indicator of a student’s ability to learn and their aptitude for academic success. These same qualities likely enable more selective scho

15535 records 649/1036 page Previous Next First page 上5页 646647648649650 下5页 Last page