• In addition to removing proteins and organelles related to

  2021-12-09

  

  In addition to removing proteins and organelles related to iron and lipid metabolism, an alternative mechanism by which autophagy promotes ferroptosis is through the formation of the BECN1-solute carrier family 7 member 11 (SLC7A11) complex [42,43]. SLC7A11 is the main component of the antiporter sy

• We used a culture model of human erythropoiesis

  2021-12-09

  

  We used a culture model of human erythropoiesis that recapitulates all developmental stages [24] to screen a focused set of lncRNAs for potential contribution to this program. We found induction of lncRNA Fas-antisense 1 (Fas-AS1 or Saf) during RBC maturation and demonstrate that essential erythroid

• br Introduction Before planning population based genetic

  2021-12-09

  

  Introduction Before planning population-based genetic analysis or GWAS, it is important to annotate the sequence of the gene because these sequences represent the major sites such as promoter and transcription factor PF-03814735 which may ultimately affect the expression of the gene. Similarly,

• Interestingly evidence has emerged recently that

  2021-12-09

  

  Interestingly, evidence has emerged recently that suggests noncanonical roles of EZH2 in various cancers. For example, in addition to histone H3, EZH2 has been shown to methylate non-histone substrates, such as Jarid2 and STAT3, to regulate their transcriptional activities (He et al., 2012, Sanulli

• At the molecular level AZ

  2021-12-09

  

  At the molecular level AZ scaffold proteins including piccolo and bassoon have been shown to directly or indirectly associate with endocytic and actin-binding proteins such as ABP1 (Fenster et al., 2003), profilin, and GIT (Podufall et al., 2014) (Fig. 2B). ABP1 and profilin, via regulating F-actin,

• In addition to the regulation of SV

  2021-12-09

  

  In addition to the regulation of SV exo- and prostaglandin agonist by Ca2+ influx retrieval of SV membranes depends on the exocytic insertion of SV components into the presynaptic membrane: If exocytic SV fusion in neurons is abrogated by genetic inactivation of the core release machinery (e.g. knoc

• br Introduction The role of histamine in allergic

  2021-12-09

  

  Introduction The role of histamine in allergic responses, anaphylaxis, and gastric AICAR phosphate mg secretion has been well described in both human and veterinary medicine. New roles for histamine and its receptors, however, have been elucidated over the last two decades (Smuda and Bryce, 2011

• br Introduction Depressive disorder is a syndrome characteri

  2021-12-08

  

  Introduction Depressive disorder is a syndrome characterized by a group of heterogeneous symptoms that affect more than 350 million people worldwide, 4% of world population (WHO, 2012). The WHO estimates depression will be the leading global cause of disability in 2020, with tremendous economic c

• The mechanisms of action of MMF and DMF are not

  2021-12-08

  

  The mechanisms of action of MMF and DMF are not well understood, but a growing body of evidence has demonstrated that DMF may act on both the neurodegenerative and inflammatory response of MS patients. The majority of the data related to the mechanism of action of DMF/MMF demonstrates the associatio

• br Acknowledgements We thank the support of the National Nat

  2021-12-08

  

  Acknowledgements We thank the support of the National Natural Science Foundation of China (NSFC) project 81501342 and support from the Disciplinary Group of Oncology and Immunology program of Xinxiang Medical University. Introduction First described as a new clinical entity in 1981, the Acqu

• In conclusion we demonstrated that extrasynaptic glutamate c

  2021-12-08

  

  In conclusion, we demonstrated that extrasynaptic glutamate could in situ affect the AA metabolism via brain CYPs. CYP1B1 and CYP2U1 genes in the astrocytes are the downstream genes of CREB, and the up-regulation of CYP1B1 and CYP2U1 expression by glutamate was due to the increases in phosphorylated

• br Regulation of Glu transporters The pivotal

  2021-12-08

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino Castanospermine receptor calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These inc

• br Conclusion and future directions GS is an important thera

  2021-12-08

  

  Conclusion and future directions GS is an important therapeutic target for the treatment of Alzheimer's disease. Its structure and function have been studied during the last years to understand the substrate cleavage mechanism to modulate the Aβ42 peptide production. The recent elucidation of GS

• Introduction Since the development of the first radioimmunoa

  2021-12-08

  

  Introduction Since the development of the first radioimmunoassay (RIA) to measure hormone levels in the late 1950s, for which Rosalyn Sussman Yalow was awarded the Nobel Prize for Medicine in 1977 (the second woman ever receiving it), the use of 5416 in molecular research has increased tremendousl

• Recent research has focused on

  2021-12-08

  

  Recent research has focused on identifying key agonists and receptors mediating nutrient-induced GLP-1 and insulin secretion. The long-chain fatty Tubastatin A HCl synthesis receptor GPR40 is the most abundant GPCR expressed in islet β cells and is also expressed on intestinal L-cells, where it con

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