• Remarkable progress has been made in the treatment of ALL

  2018-11-14

  

  Remarkable progress has been made in the treatment of ALL. Currently, the five-year overall survival rates exceed 85% in pediatric patients in developed countries (Pui et al., 2015), but remain less than 45% in adults (Jabbour et al., 2015; Bassan and Hoelzer, 2011).The poor outcome in adults has be

• Lung cancer is the most common

  2018-11-14

  

  Lung cancer is the most common cancer in US and worldwide (Centers for Disease Control and Prevention and National Center for Health Statistics, 2013; American Cancer Society, 2014), and the survival rate is low (Howlader et al., 2013). Most cases (90%) of lung cancer are attributable to smoking (Ge

• Regarding the prognostic value of

  2018-11-14

  

  Regarding the prognostic value of CTC, detection of CTCs over the threshold value (CTC+ patients) in both the FCMC and CellSearch system was a worse prognostic factor in this study. The significant point that needs to be noted here is that the hazard ratio between CTC+ and CTC− patients using the FC

• The extracellular matrix ECM is important for the integrity

  2018-11-14

  

  The extracellular matrix (ECM) is important for the integrity of the aortic wall and mutations in ECM genes such as Fibulin-4 and Fibrillin-1 hence lead to aneurysm formation. Genetic studies in Fibulin-4 and Fibrillin-1 mutant mice implicated dysregulation of the TGF-β pathway as an important hallm

• br Materials Methods br Results We sequenced

  2018-11-14

  

  Materials & Methods Results We sequenced the exomes of 59 Greek (GR) and 15 German (DE) patients with validated bacterial sepsis/organ dysfunction according to the new Sepsis-3 definition (Seymour et al., 2016; Shankar-Hari et al., 2016; Singer et al., 2016). Each cohort included two groups of

• Traditionally serologic assays were designed to

  2018-11-14

  

  Traditionally, serologic assays were designed to detect SB203580 manufacturer against flavivirus structural proteins, especially viral E protein in the context of virions. A number of previous studies suggest that antibodies against flavivirus nonstructural proteins may be virus-type specific (Garci

• Palivizumab an antibody drug targeting antigenic

  2018-11-14

  

  Palivizumab, an antibody drug targeting antigenic site II of the RSV fusion protein (F protein), is available for the prevention of severe RSV illness in certain infants and children who are at high risk. The drug can help prevent development of serious RSV diseases, yet with limited efficacy (Groot

• br Introduction Influenza comprises a substantial portion of

  2018-11-14

  

  Introduction Influenza comprises a substantial portion of morbidity and mortality caused by acute respiratory infections, which are the fourth leading cause of death and the second highest cause of years of life lost (Organization, 2014; Radin et al., 2012; Nair et al., 2011). Severe influenza di

• BCG has been integrated into the Expanded Immunization

  2018-11-14

  

  BCG has been integrated into the Expanded Immunization Program of WHO since 1974 and neonatal vaccination with BCG is still used to prevent TB in countries with a high burden of TB (Marais et al., 2016). Correspondingly, adolescents and adults with LTBI always occur epidemiologically following inocu

• Then all calculations were performed using R

  2018-11-14

  

  Then, all calculations were performed using R v.3.1.1 (R Development Core Team, 2011; http://cran.r-project.org) [1]. Experimental design, materials and methods In metabolic profiling, there is no single platform or method to analyze the entire metabolome of a biological sample, mainly due to th

• br Data CMP experiments were performed on the titanium plate

  2018-11-14

  

  Data CMP experiments were performed on the titanium plates by altering the sample surface through various CMP conditions [1]. First, slurry particle size and stability were evaluated through particle light scattering based particle size measurement by using Coulter LS 13 320 equipment as can be s

• Here we use T weighted EPI T to characterize

  2018-11-14

  

  Here we use T2*-weighted EPI (T2*) to characterize age-related differences in the neurophysiology of the human adolescent striatum in vivo using a multivariate pattern analysis approach. Specifically we use spatial patterns of striatal T2* to generate highly significant age predictions from both tas

• br Sexual development motivates risk taking

  2018-11-14

  

  Sexual development motivates risk-taking Because late adolescence and early adulthood is a period of peak fertility, reproductive success or failure in this period has an outsize influence on lifespan reproductive fitness, and adolescent behaviors have undergone strong selection pressure. Through

• br Methods br Results br Discussion In a transdiagnostic sam

  2018-11-14

  

  Methods Results Discussion In a transdiagnostic sample of anxious youth, greater laboratory-assessed vigilance to threat was associated with greater real-world use of avoidance (distraction and suppression) in the wake of negative events. Given the high clinical relevance of real-world avoi

• In addition individuals who experienced CSA and who develop

  2018-11-13

  

  In addition, individuals who experienced CSA and who develop CSA-related Post-Traumatic Stress Disorder (PTSD) are at increased risk to develop subsequent internalizing disorders (Lindert et al., 2014), which makes internalizing disorders and CSA-related PTSD overlapping in symptomatology. This, in

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