• The generation of autoantibodies to TAAs is not fully unders

  2018-10-23

  

  The generation of autoantibodies to TAAs is not fully understood. TAA proteins are most likely either mutated, overexpressed, post-translationally modified, misfolded, aberrantly cleaved, or aberrantly localized in tumor LY335979 cost (Casiano et al., 2006). It has been reported that HSP60 localize

• We have now successfully found a previously unknown family o

  2018-10-23

  

  We have now successfully found a previously unknown family of non-platinum-based anticancer compounds (called FMD compounds) as potent antitumor agents for natural targeted chemotherapy without the need of using an antibody to bind to cancer cells. Upon entering normal and abnormal (cancer) cells, t

• Despite all the progress made in

  2018-10-23

  

  Despite all the progress made in the last decade, it is very unlikely that the MDG targets will be met in many LMICs, where 99% of global deaths occur (You et al., 2013). In countries with a high burden of neonatal and child mortality, a variety of interventions could substantially reduce deaths and

• Current therapies for the treatment of

  2018-10-23

  

  Current therapies for the treatment of HPV infection of the ano-genital tract are mainly ablative and devoted to the removal of damaged HPV-infected lesions, such as warts and squamous intraepithelial lesions (Krogh von et al., 2000). However, most patients are not featured by macroscopic lesions. I

• In human cancer ABCB P gp ABCC multidrug resistance associat

  2018-10-23

  

  In human cancer, ABCB1/P-gp, ABCC1/multidrug resistance-associated protein 1 (MRP1), and ABCG2/breast cancer resistance protein (BCRP) are well-known causes of multidrug resistance to multiple chemotherapeutic agents, such as taxane and vinca alkaloids (Gottesman et al., 2002). Therefore, much effor

• Over the two centuries we have observed that the

  2018-10-23

  

  Over the two centuries, we have observed that the DEP in Athens, Malága, and Rome are consistently over the threshold during part of the year. Nice stands out as having the most dramatic rise; by the 2060, Nice would surpass the intensity of the three Southern European cities; by the end of this jak

• Some of the identified signals can be attributed to

  2018-10-23

  

  Some of the identified signals can be attributed to confounding by indication. This is most notable for the observed associations with lung cancers. As an example, drugs used to treat obstructive lung diseases exhibited a strong association with squamous cell carcinoma of the lung (OR, 2.61), which

• The significant SNPs lie in non coding

  2018-10-23

  

  The significant SNPs lie in non-coding regions, as is common in GWAS where ~64% of identified SNPs lie in enhancer regions (Hnisz et al., 2013). Gene enhancer elements are noncoding segments of DNA involved in regulating transcriptional programs (Corradin and Scacheri, 2014). Their location is predi

• br Genetic Variability of HEV and Clinical Implication Seven

  2018-10-23

  

  Genetic Variability of HEV and Clinical Implication Seven HEV genotypes are recognized within the Orthohepevirus A species based on the guanidine hydrochloride of entire viral genomes (HEV-1 to HEV-7) (Smith et al., 2016). Four HEV genotypes (HEV-1 to HEV-4) are well recognized as human pathogen

• Secondary TMS outcome measure cortical

  2018-10-23

  

  Secondary TMS outcome measure cortical excitability has previously been shown to decrease following TBI (De Beaumont et al., 2007; Chistyakov et al., 2001; Bernabeu et al., 2009; Livingston et al., 2010), yet we demonstrated no such change following ball heading. The reason why changes were seen in

• Conflict of Interest br Chronic

  2018-10-23

  

  Conflict of Interest Chronic immune activation is a hallmark of HIV infection (). Tumor necrosis factor (TNF) alpha is a proinflammatory cytokine detected throughout the disease course in plasma and lymph nodes of HIV-infected patients. The HIV-1 Nef protein is produced early during the disease a

• To reveal the molecular mechanism of MeCP

  2018-10-23

  

  To reveal the molecular mechanism of MeCP2 regulation, we performed a combination of microarray analysis and ChIP-Seq, through which we identified FOXF1 and MYOD1 as MeCP2 targeting genes. We confirmed that MeCP2 binds to the methylated CpG islands in the promoter regions of both genes, leading to d

• Furthermore whilst DNA sequencing provides an extended

  2018-10-23

  

  Furthermore, whilst DNA sequencing provides an extended view of the microbiome, it is limited in providing information on “which microorganisms” maybe directly contributing to infection. This is increasingly important when analysing our data set where regardless of the spectrum of activity of antim

• Oxysterols serve as endogenous ligands of liver

  2018-10-23

  

  Oxysterols serve as endogenous ligands of liver X receptors (LXRα (NR1H3)/LXRβ (NR1H2)) (Janowski et al., 1996). In addition to their established role in cholesterol metabolism (Janowski et al., 1999), LXRs also suppress inflammatory gene expression, thus controlling immune response and inflammation

• Here we report that the Tim galectin autocrine loop is

  2018-10-23

  

  Here we report that the Tim-3-galectin-9 autocrine loop is activated in AML FMK through protein kinase C (PKC)/mTOR pathways. These pathways trigger translation of both Tim-3 and galectin-9 and induce high levels of galectin-9 secretion as well as the release of soluble Tim-3. Importantly, this eff

15841 records 1052/1057 page Previous Next First page 上5页 10511052105310541055 下5页 Last page